Bissouma has made 17 appearances for Brighton and scored one goal across all competitions in the 2020-21 season.
The Seagulls will take on Manchester City in a Premier League game on Wednesday evening without the Mali international.
The midfielder was suspended for the encounter after picking his fifth yellow card of the campaign in their draw against Wolverhampton Wanderers.
Brighton manager Potter revealed his side would miss the 24-year-old at the Etihad Stadium and praised him for his recent impressive performances.
Yves has been performing well, he has taken a step forward in terms of his own performance levels. We missed him earlier in the season when he missed three games,” Potter told the club website.
We haven't got another Yves Bissouma. Clearly, you want as many good players as you can on the pitch against Man City and we are disappointed not to have Yves. But we have got other good players that are ready and want to play.
We just have to find the right combination to be competitive against one of the best teams in the world.”
Bissouma teamed up with the Seagulls in the summer of 2018 from French side Lille and has been a key member of the team.
The Ecuadorian side's general manager has been quoted claiming "everything is closed" with a Premier League club and that they will make an announcement in the next few days.
The fee for his transfer is said to be £4.5m and the deal includes a clause that will see Independiente recoup a significant percentage of any sell-on fee.
There have also been discussions over him joining Belgian club Royale Union Saint-Gilloise, who are also owned by Brighton owner Tony Bloom, on loan for the rest of the season.
With South American markets opening up to British clubs following Brexit, Caicedo had been scouted by many in the Premier League including Man Utd.
At just 19 years old, Caicedo already has four caps for Ecuador and played the majority of minutes for his club in the Copa Libertadores and Ecuadorian top-flight in 2020, so would be confident of gaining a work permit.